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Chickscope
Chickscope is a project to study chicken embryo development using a remotely-controlled magnetic resonance imaging (MRI) instrument. It is being developed by educators and researchers from several departments at the University of Illinois at Urbana-Champaign in collaboration with Illinois teachers. The site includes many egglectic and engaging educational resources such as annotated chicken embryology sequences and EggMath, collection of Web modules (including many interactive applets), intended for use in K-12 classrooms, covering different topics in mathematics related to eggs.

E-School
Created in 1996 by Maui High Performance Computing Center and Hawaii State Department of Education (HSDOE) through a U.S. Department of Education Challenge
Grant for Technology, E-School is a virtual school accessed over the Internet. Over 20 courses, targeted at high school students, are offered during the school year, including topics such as Shakespeare, computer programming, geometry, Hawaiian history, and journalism. 
River Web
Maryland Virtual High School offers a river basin ecology simulation and curriculum package: River Web. Includes group exercises in data collection, modeling and interpretation.
GirlTECH
GirlTECH, the highly acclaimed computational science summer workshops for teachers hosted by Rice University's Center for Research on Parallel Computation (CRPC), currently makes available a large and diverse collection of online lesson plans generated by participants over several years. Lesson and project plans suitable for early elementary through high school levels can be found that span the physical, mathematical, biological and natural sciences, often emphasizing scientific observation and computer/Internet usage. Includes search engine.
See Also: http://math.rice.edu/~lanius/Lessons/
Project SUCCEED completed workshops and projects
View student work, pictures and summaries of all activities from every SUCCEED (Stimulating Understanding of Computational Science through Collaboration, Exploration, Experiment, and Discovery) workshop that the Shodor Education Foundation has conducted over the past three years. Although the material here is not structured or intended as ready-to-use classroom lesson plans, the course descriptions, daily overviews, reports and images contained within yield a trove of ideas for others considering orchestrating similar workshops. Also see Project SUCCEED's STELLA models online.
MARINER K-12 Lesson Plans
 

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